產(chǎn)品詳情

  • 產(chǎn)品名稱：EDG-2

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  • 產(chǎn)品廠商：KamiyaBiomedical
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簡單介紹：
EDG-2
詳情介紹：
Alternative Name EDG-2
Background EDG-2 Transfected Cell Positive Control Lysate. Provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-Mercaptoethanol. Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysopholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca 2+ ]i by augmenting phos- pholipase C through Gq/11 and beta/gamma dimmers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Application Notes For use as a positive control with EDG-2 polyclonal antibody ABIN187787 for Western blot analysis. Use 10 μl of EDG-2 cell lysate per lane as a control for using EDG-2 antibody.
Restrictions For Research Use only
Format Liquid
Buffer Cell lysate provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol.
Storage -20 °C