產(chǎn)品詳情

  • 產(chǎn)品名稱：Beta-SecretaseInhibitor

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：KamiyaBiomedical
  • 產(chǎn)品文檔：
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簡單介紹：
Beta-SecretaseInhibitor
詳情介紹：
Purpose Beta-Secretase Inhibitor
Sequence Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-(Statine)- Val-Ala-Glu-Phe-OH
Characteristics This inhibitor has demonstrated potent beta - secretase inhibition (IC50 ~30 nM) under the following conditions. Buffer: 20 nM sodium acetate, pH 4.8, 0.06% Triton X-100. Substrate: MBPAPPC125 recombinant fusion protein, 10 μg/mL. The fusion protein contains a C-terminal fragment of myelin basic protein (MBP) and the 124 amino acid C-terminal fragment of amyloid precursor protein (APPC123). Inhibitor: Tested at concentrations ranging from 1 μM to <0.01 1="" 2="" μm.="" dmso="" was="" present="" at="" a="" final="" concentration="" of="" 2%.="" incubation:="" 37°c,="" to="" hours.="" <="" td="">
Purity 98 +/- 1 % by HPLC
Formula C73H118N16O27
Solubility DMSO
Molecular Weight 1651 g/mol
Restrictions For Research Use only
Format Solid
Reconstitution We recommend reconstitution in DMSO because DMSO may be required to maintain solubility of the inhibitor in beta-secretase activity assays.
Storage RT